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Eugene I. Shakhnovich
Department of Chemistry and Chemical Biology
Harvard University
12 Oxford Street
Cambridge, MA 02138
Tel: (617) 495-4130
Fax: (617) 384-9228
E-mail: eugene@belok.harvard.edu
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PEOPLE: CURRENT LAB MEMBERS
Dima Lukatsky, PhD
Postdoctoral Fellow
Department
of Chemistry and Chemical Biology
Harvard University
12 Oxford St.
Cambridge, MA 02138
Tel: (617) 384-
Fax: (617) 384-9228
lukatsky@fas.harvard.edu
We investigate the problem of specificity
of protein-protein interactions. In a
living cell thousands of different proteins interact with each other with
extraordinary degree of specificity. Nature has created proteins in such a way
that non-specific (unwanted) interactions are suppressed. The key question is
what are the design principles that Nature uses to provide such a high
specificity of protein-protein interactions and to avoid the putative
interactions. This fundamental question is of great practical significance for
the drug-design applications.

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